Essentials By Catalina

Matrixyl ® 3000

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Restores skin’s metabolism of youth.
New study reconfirms previous findings.

Matrikines anti-wrinkle complex helps reverse the chronological aging as attested by the regulation of senescence markers and reduce the cutaneous photo damage by restructuring the fragile network of the papillary dermis. Matrixyl® has received the in-cosmetics 25 years of Innovation Award in 2015.

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Price2:Starting at: $31.00

Product Description

Matrixyl®3000 supports the activation of the cutaneous repair process, and in particular at the level of the fragile and UV-damage prone papillary dermis. Matrixyl®3000 promotes wrinkle smoothing and improves tone and elasticity.

Matrikines: the key to anti-aging
In 1999, the French Professor Maquart and his team published their first article mentioning “matrikines”. What does this term designate? A matrikine is a small molecule composed of a short sequence of amino-acids, a peptide, derived from the surrounding extracellular matrix and constituting a signal in order to regulate cell activity. Matrikines play an important role in the wound healing process and connective tissue remodeling.

Matrikines are messenger peptides capable of regulating cell activities by interacting with their specific receptors. They activate certain genes involved in the process of extracellular matrix renewal and cell proliferation. These mechanisms become weaker and weaker with age.
What is Matrixyl ®?
Matrixyl® is a trade mark of Sederma SAS and offered to you at wholesale volume by Essentials by Catalina. It designates an anti-wrinkle active ingredient for cosmetics containing a specific matrikine which cosmetic nomenclature denomination is palmitoyl pentapeptide-4 (palmitoyl pentapeptide-3 before 2006). It contains a peptide of 5 aminoacids linked to a 16-carbon chain for improving the penetration of the molecule through the lipidic structures of the skin.

Matrikines anti-wrinkle complex helps reverse the chronological aging as evidenced by the regulation of senescence markers and the reduction of the cutaneous photo damage by restructuring the fragile network of the papillary dermis. Matrixyl® has received the in-cosmetics 25 years of Innovation Award in 2015.

Skin Conditioning
Active Ingredients
Consumer Benefit

Anti-wrinkle Products
Eye Contour Care
Face / Neck Skin Care
After Sun
Sun Protection

Product Detail
Form at 25°C/77°F - Liquid
Chemistries - Peptides
Formulation - Water Soluble
Recommended Use Level - 3%
How does it work?
In order to react to their environment or to internal stimuli and regulate their activity, the cells use several clearly defined signalling pathways that will transfer information from the cell surface to the internal effector system, most of the time the genes. Thus, a matrikine peptide can link to a matching cell-surface receptor which is coupled to a transducer to relay information into the cell using various signalling pathways (TGF-β, PI3K for example in the case of collagen-1). So it works like a key and a keyhole. It means that the structure of the matrikine is important. Different matrikines can trigger different messages.

Matrikine peptides act from the inside to provide long term effects against skin aging.

Matrikine peptide is recognised by a cell membrane receptor and binds to the receptor. It triggers intracellular action that:

Promote tissue repair
Participate in wound healing
Stimulate macromolecule synthesis

Bases That Pair Well With Matrixyl 3000

Facial Moisturizer Base - Dry to Normal Skin

This formulation combines several naturally derived ingredients and compounds for outstanding effectiveness.

A superb combination of extracts adds even more benefits. 

Hydra-M Advanced Mineral Face Mask 

Formulated with an active, multi-mineral, chrono-energizing blend of Zinc, Copper and Magnesium. This mineral rich mask works synergistically to improve your skin's vitality and also aid as a booster for active ingredients. 

Botanical Facial Cleanser

A luxurious base that gently cleanses the skin. Our Sulfate Free Base is formulated with mild ingredients for all skin types, even sensitive skin. An invigorating blend of natural Botanical Extracts will refresh and tone your skin. 

Aloe Gel Base

Our clear and moisturizing Aloe Vera Gel Base is non-sticky and pH balanced. Our glycerin enriched formula is oil free and perfect for after sun soothing products, especially when infused with Botanical Extracts of your choice.

New in vivo test reveals age gain by 2 years in just 1 month

Mid 2011, a new proof of the efficiency of Matrixyl® 3000, the famous peptide blend, was made available. This time, it was its ability to help repair the UV damage-prone papillary dermis that was demonstrated.

The papillary dermis, located just under the dermis/epidermis junction (DEJ), is more fragile than the reticular dermis and is intensely affected by photo aging. Papillary fibroblasts are fundamental to promote epidermal morphogenesis and wound healing that is why papillary dermis repair delivers visible anti-wrinkle benefits.
In vivo studies have revealed the positive matrix reinforcing effect of Matrixyl® 3000 by measuring the SLEB density (Subepidermal Low Echogenic Band that corresponds to the papillary dermis). A significant improvement corresponding to a gain in age of 1.8 years is visible in just one month, and confirmed after 2 months: the photo-induced aging is then delayed by 5.5 years.
Another analysis of the papillary dermis by confocal laser microscopy has shown that Matrixyl® 3000 helps reduce the fibre fragmentation and notably supports the reconstruction of the papillary dermal fibre network.
2013: New study confirms previous findings

A complementary approach is confirming Matrixyl® 3000’s repairing effect of the cutaneous damages of aging. Now it is its ability to reverse chronological aging that has been demonstrated with both in vitro and ex vivo studies.

First, Matrixyl® 3000 has been shown to regulate the expression of well-known (SA β-galactosidase) and recently discovered (progerin) markers of senescence. Progerin is an altered form of the lamin A protein (lamins are key proteins in the skin’s regenerative process). With age, progerin's expression rises, as well as the skin tissue disorganisation. Matrixyl® 3000 does not only reduce the SA β-galactosidase activity, but it also reduces the progerin's expression while preserving the expression of the normal form lamin A.

Then, immunohistochemistry analysis of skin sections (ex vivo study) has proved that Matrixyl® 3000 significantly stimulates synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins. While these proteins of the dermis and dermal-epidermal junction usually decrease with age, Matrixyl® 3000 rejuvenates the dermal structure and tends to make aging skin behave like young skin.
Matrixyl® 3000 restores skin’s metabolism of youth. These innovative tests and claims give you one more reason to claim “Matrixyl® inside” on your products.
Tests November 2015
Ex vivo tests

Quantification of constituent, anchorage and cohesion proteins of the dermis and dermal-epidermal junction on skin explants (n=10, from 30 to 66 years).

In vitro tests
  • Study on senescent fibroblast with Matrixy®3000 eq 5%

  • SA β-galactosidase (fluorescence method) ..........................-56%, p<0.01
  • Progerin (RNA expression) ..................................................-27%, p<0.05
  • Lamin A (RNA expression) .........................................................+4%, ns
With Matrixyl®3000, aging skin tends to behave like young skin.
In vivo tests

28 female volunteers aged from 51 to 72 years, mean age 59. Twice daily application of a cream containing 3% of Matrixyl®3000 for 2 months to one half of the face and the forearm (inner and UV-exposed outer forearm) against placebo.

ANALYSIS OF THE Subepidermal Low Eshogenicity Band

Significant improvement of the SLEB characteristics in just one month (thickness: -5.5%/placebo; density: +7.8%/placebo, on the inner arm) and confirmed after two months. The aging process is slowed downby 1.8 years in just one month.

Measurements of the fibre defragmentation by confocal laser microscopy (Vivascope) on the face, next to the external eye corner.

Matrixyl®3000 helps reduce the fibre fragmentation and notably supports the reconstruction of the papillary dermal fibre network.

23 female volunteers aged from 42 to 67 years / Twice daily application on one half of the face of a cream containing 3% of Matrixyl®3000 against placebo, for 2 months. Assessment of the anti-wrinkle efficacy by profilometry, cutometry and photography compared to T0.

The repairing effect of Matrixyl®3000 promotes the visible quality of the skin by decreasing the appearance of wrinkles and improving tone and elasticity.
Non-warranty: The information in this publication is believed to be accurate and is given in good faith, but no representation or warranty as to its completeness or accuracy is made. Suggestions for uses or applications are only opinions. Users are responsible for determining the suitability of these products for their own particular purpose. No representation or warranty, expressed or implied, is made with respect to information or products including, without limitation, warranties of merchantability, fitness for a particular purpose, non-infringement of any third party patent or other intellectual property rights including, without limit, copyright, trademark and designs. Any trademarks identified herein, unless otherwise noted, are trademarks ©2015 Sederma

Additional Information

Unit Size 2oz 8oz 16oz
Country of Origin France

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Product questions

The matrixyl 3000. Is this product to be used with other products as a base or is it for use alone. If it needs to be mixed with a base, would the ACE lotion work for it? Also, how much do I use?

Hello Kathy,

Matrixyl 3000 is an additive that is generally used at 3% in formulations. It will work in the ACE, however most people use this ingredient in formulations that are specifically designed for the face. I've listed a link below to our listing for the Matrixyl 3000 which is filled with useful information, such as use rate, and mixing instructions.

Thank you

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