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Matrixyl ® 3000
Matrixyl® 3000 is one of the most effective, proven anti-aging peptides. This is a must have ingredient for your face lotion and serum formulations.
Description
Matrixyl ® 3000
As we age, our skin cells slowly lose their ability to repair tissue and heal wounds. It becomes harder to fight the UV damage that causes premature aging. Matrixyl®3000 stimulates wrinkle smoothing and improves tone and elasticity, effectively restoring its youthful appearance and metabolism.
In short, it helps aging skin behave like younger skin.
Matrikines: the key to anti-aging
In 1999, French scientists discovered the role Matrikines play in the wound healing process and connective tissue remodeling. Matrikines are messenger peptides capable of regulating cell activity by interacting with specific receptors. They activate certain genes involved in cellular renewal and proliferation, mechanisms which become progressively weaker with age.
What is Matrixyl®?
Matrixyl® is trademarked by Sederma SAS and offered to you at wholesale volume by Essentials by Catalina. It is technically described as an anti-wrinkle active ingredient for cosmetics containing the matrikine palmitoyl pentapeptide-4. It contains a peptide composed of 5 amino acids linked to a 16-carbon chain that improves the penetration of the molecule through the skin.
This anti-wrinkle complex helps reverse chronological aging as evidenced by the regulation of senescence markers and the reduction of cutaneous photo damage by restructuring the fragile network of the papillary dermis. Matrixyl® received the In-Cosmetics 25 years of Innovation Award in 2015.
How does it work?
In order to react to their environment or to internal stimuli and regulate their activity, the cells use several clearly defined signaling pathways that will transfer information from the cell surface to the internal effector system, most of the time the genes. Thus, a matrikine peptide can link to a matching cell-surface receptor which is coupled to a transducer to relay information into the cell using various signaling pathways (TGF-β, PI3K for example in the case of collagen-1). So it works like a key and a keyhole. It means that the structure of the matrikine is important. Different matrikines can trigger different messages.
Matrikine peptides act from the inside to provide long term effects against skin aging.
Matrikine peptide is recognised by a cell membrane receptor and binds to the receptor. It triggers intracellular action that:
- Promote tissue repair
- Participate in wound healing
- Stimulate macromolecule synthesis
Applications:
- Anti-wrinkle Products
- Eye Contour Care
- Face / Neck Skin Care
- After Sun
- Sun Protection
Product Details:
- Liquid at 25°C/77°F
- Chemistry: Peptide
- Formulation: Water Soluble
- Recommended Use Level: 3 - 4%
- Mix in cold or when the base is at 45°C or less.
- Mix until fully dissolved.
Additional Notes
These are only suggested usage rates. Each formulation is different and you must test in small batches to find the percentages that work best for you. Always start by mixing in a low percentage, then gradually add until you reach your desired result.
Use this batch calculator to help you determine exactly how much you need to use of this ingredient for your next batch.
Batch Calculator
Ingredients
- ↕ % 5.00
- ↕ % 3.00
- ↕ % 2.00
Product Suggestions
Technical
Product Profile
Physical characteristics and solubility
Gel
Opalescent
Off-White
Water-Soluble
4.0 – 6.0
1.140 – 1.160 @ 20°C
France
Ingredients
Common and INCI names for your product label
Glycerin, Deionized Water, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7
Glycerin, Water, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7
The copy button copies the INCI declaration.
Storage & Shelf Life
How to keep this peptide complex stable batch to batch
Dry, well-ventilated place, protected from light
1 Year
Keep It Sealed
Store in the original container. Once opened, reseal carefully and keep upright to prevent leakage.
Consider Refrigeration for Long-Term Storage
The manufacturer recommends 4–7°C (39–45°F) for long-term storage, protected from light. Room temperature is fine for near-term use.
Mix in Cold or Below 45°C
Add during the cool-down phase, when the base is at 45°C or less, and mix until fully dissolved.
Test Before Scaling
Run a small batch first to confirm stability in your specific formulation before committing to a full production run.
Quality & Compliance
Regulatory status at a glance
Not Classified
Not irritating (human patch test)
Does not cause sensitization (HRIPT)
> 100°C (non-flammable in normal use)
Slight eye irritation on in vitro testing (HET-CAM) with low cytotoxicity; not mutagenic (Ames test). Not PBT or vPvB.
Science & Claim Substantiation
Clinical and lab testing behind the Matrixyl® 3000 claims (Sederma)
Repairs the Papillary Dermis
The papillary dermis is the thin, fragile layer just below the skin's surface that takes the brunt of UV damage over time — repairing it is what actually shows up as fewer visible wrinkles. In a 2-month study, 28 women (ages 51–72) applied a cream with 3% Matrixyl® 3000 to one side of the face and forearm, with a placebo on the other side. Ultrasound imaging of the papillary dermis (the SLEB) showed a significant improvement in just one month — thickness down 5.5% and density up 7.8% versus placebo — equivalent to reversing about 1.8 years of skin aging, holding at two months.
Rebuilds the Skin's Fiber Network
Using confocal laser microscopy near the outer corner of the eye, the same study found Matrixyl® 3000 reduces fiber fragmentation and supports rebuilding the papillary dermis's fiber network — the structural scaffolding that keeps skin looking firm.
Turns Down Aging Signals at the Cell Level
In a lab study on aged (senescent) skin cells, a 5% concentration of Matrixyl® 3000 measurably reduced two markers that rise as skin ages, while preserving a protein the skin needs to stay healthy:
-56% (p<0.01)
-27% (p<0.05)
+4% (not significant)
Boosts Collagen at the Dermal-Epidermal Junction
On skin explants, Matrixyl® 3000 significantly increased synthesis of Collagen-I, -IV, -VII, -XVII, and Nidogen-I — proteins that normally decline with age and hold the dermis and epidermis together.
Visible Anti-Wrinkle Results
23 women (ages 42–67) applied a cream with 3% Matrixyl® 3000 to one half of the face against a placebo, twice daily for 2 months. Measured by profilometry, cutometry, and photography, the treated side showed fewer visible wrinkles and better tone and elasticity.
Matrixyl® is a registered trademark of Sederma. Testing summarized here was conducted by Sederma; suggestions for use are opinions only, and you're responsible for determining suitability for your own formulation.
Disclaimer: The technical specifications above reflect standard production values and may vary slightly between batches. Always conduct your own small-batch testing and stability studies before scaling up to production.
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Can you give me the ingredients for your matrixyl-3000? Thank you -
The Matrixyl 3000 ingredient deck can be found under the “Technical” tab on the Matrixyl page.
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How much would I need to add to a 2 oz lotion. Drops? Not sure how concentrated it is. -
When using additives, extracts, vitamins, peptides, etc. you always want to consult the usage rates posted on their respective pages. The Recommended Use Level for Matrixyl 3000 is: 3 – 4% in your formulation.
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Is there a sample size for eyeliss or matrixyl? thanks
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Good Morning, unfortunately we do not offer samples of raw materials or ingredients, only finished product. Matrixyl 3000 is an anti-aging peptide with proven benefits over time, and we do offer a 2 ounce size. Thank you
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Andrea
Oh Yess! Love this
Christine
It Works!
Christine
Love Matrixyl 3000