Matrikines are messenger peptides capable of regulating cell activities by interacting with their specific receptors. They activate certain genes involved in the process of extracellular matrix renewal and cell proliferation. These mechanisms become weaker and weaker with age.
Matrikines anti-wrinkle complex helps reverse the chronological aging as evidenced by the regulation of senescence markers and the reduction of the cutaneous photo damage by restructuring the fragile network of the papillary dermis. Matrixyl® has received the in-cosmetics 25 years of Innovation Award in 2015.
Eye Contour Care
Face / Neck Skin Care
Chemistries - Peptides
Formulation - Water Soluble
Recommended Use Level - 3%
Matrikine peptide is recognised by a cell membrane receptor and binds to the receptor. It triggers intracellular action that:
Promote tissue repair
Participate in wound healing
Stimulate macromolecule synthesis
Facial Moisturizer Base - Dry to Normal Skin
This formulation combines several naturally derived ingredients and compounds for outstanding effectiveness.
A superb combination of extracts adds even more benefits.
Hydra-M Advanced Mineral Face Mask
Formulated with an active, multi-mineral, chrono-energizing blend of Zinc, Copper and Magnesium. This mineral rich mask works synergistically to improve your skin's vitality and also aid as a booster for active ingredients.
Botanical Facial Cleanser
A luxurious base that gently cleanses the skin. Our Sulfate Free Base is formulated with mild ingredients for all skin types, even sensitive skin. An invigorating blend of natural Botanical Extracts will refresh and tone your skin.
Aloe Gel Base
Our clear and moisturizing Aloe Vera Gel Base is non-sticky and pH balanced. Our glycerin enriched formula is oil free and perfect for after sun soothing products, especially when infused with Botanical Extracts of your choice.
Mid 2011, a new proof of the efficiency of Matrixyl® 3000, the famous peptide blend, was made available. This time, it was its ability to help repair the UV damage-prone papillary dermis that was demonstrated.
The papillary dermis, located just under the dermis/epidermis junction (DEJ), is more fragile than the reticular dermis and is intensely affected by photo aging. Papillary fibroblasts are fundamental to promote epidermal morphogenesis and wound healing that is why papillary dermis repair delivers visible anti-wrinkle benefits.
In vivo studies have revealed the positive matrix reinforcing effect of Matrixyl® 3000 by measuring the SLEB density (Subepidermal Low Echogenic Band that corresponds to the papillary dermis). A significant improvement corresponding to a gain in age of 1.8 years is visible in just one month, and confirmed after 2 months: the photo-induced aging is then delayed by 5.5 years.
Another analysis of the papillary dermis by confocal laser microscopy has shown that Matrixyl® 3000 helps reduce the fibre fragmentation and notably supports the reconstruction of the papillary dermal fibre network.
First, Matrixyl® 3000 has been shown to regulate the expression of well-known (SA β-galactosidase) and recently discovered (progerin) markers of senescence. Progerin is an altered form of the lamin A protein (lamins are key proteins in the skin’s regenerative process). With age, progerin's expression rises, as well as the skin tissue disorganisation. Matrixyl® 3000 does not only reduce the SA β-galactosidase activity, but it also reduces the progerin's expression while preserving the expression of the normal form lamin A.
Then, immunohistochemistry analysis of skin sections (ex vivo study) has proved that Matrixyl® 3000 significantly stimulates synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins. While these proteins of the dermis and dermal-epidermal junction usually decrease with age, Matrixyl® 3000 rejuvenates the dermal structure and tends to make aging skin behave like young skin.
Quantiﬁcation of constituent, anchorage and cohesion proteins of the dermis and dermal-epidermal junction on skin explants (n=10, from 30 to 66 years).
- REGULATION OF SENESCENCE MARKERS Study on senescent fibroblast with Matrixy®3000 eq 5%
- SA β-galactosidase (fluorescence method) ..........................-56%, p<0.01
- Progerin (RNA expression) ..................................................-27%, p<0.05
- Lamin A (RNA expression) .........................................................+4%, ns
- REPAIR OF THE PAPILLARY DERMIS
- ANALYSIS OF THE FIBRE NETWORK
- ANTI-WRINKLE EFFICACY, SKIN TONE AND ELASTICITY
|Unit Size||2oz 8oz 16oz|
|Country of Origin||France|
- The matrixyl 3000. Is this product to be used with other products as a base or is it for use alone. If it needs to be mixed with a base, would the ACE lotion work for it? Also, how much do I use?