Essentials By Catalina

Biopeptide EL™

SKU: RAW2045

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We will no longer be stocking Biopeptide ELTM . Our Lab has sourced a more advanced, better researched Peptide Compound that will replace it and the Biopeptide CLTM, which is also being discontinued. We are very excited to offer you all this great new active ingredient in the very near future. There will be a link to it from this page, as well as an email announcement that will be sent out to everyone when we have it in stock.     *******

The "spring fragment" of Elastin for dermal restructuring.
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Product Description

Biopeptide EL™

The "Spring Fragment" of Elastin For Dermal Restructuration

Function & Characteristics: Firmness and Tone improvement. Hydroglycolic solution of Palmitoyl - Val - Gly - Val - Ala - Pro - Gly titrated at 100 ppm .VGVAPG is a matrikine, a peptide messenger notably involved in the process of cutaneous repair. VGVAPG is the "spring fragment”, repeated six times in the whole elastin molecule.
Cosmetics Interest: BIOPEPTIDE EL stimulates fibroblasts' mobility and is known for helping increase skin suppleness.
Properties: Dermal restructuration based on cell communication. The chemotactic effect of VGVAPG potentiates the fibroblasts' activity of macromolecule synthesis.
Applications: Skin firming products, eye contour products and hand care products.
Formulation: Water soluble. Incorporate into Emulsion Bases at 45°C and Gel Bases at room temperature.
Recommended Use Levels: 2% -5%
Glyceryl Polymethacrylate: A film former and viscosity agent often used in gels because of its strong hydrating power and high water absorbing capacity. Glyceryl Polymethacrylate can help reconstruct the dermis and increase its firmness as it contains a natural fragment of elastin. It can also be used to fight premature aging by reinforcing the skin's natural resistance and integrity.

PEG-8: The polyethylene glycol ester of Lauric Acid used in cosmetics and beauty products as a surfactant, thickener and emulsifying agent.

Palmitoyl Oligopeptide: This synthetic peptide, meaning it is man-made, consists of the amino acids glycine, glutamine, proline and arginine. Palmitoyl oligopeptide is actually a fragment of collagen that is attached to palmitic acid, which makes it more stable while also enhancing its ability to bind to human skin. The main function of palmitoyl oligopeptide is the restructuring of cutaneous tissues. When the synthesis of these proteins is stimulated, the effects are smoother, wrinkle-free rejuvenated-looking skin.
  • Appearance : Opalescent Gel
  • Colour : Colourless
  • Odour : Characteristic
  • PH (sol. at 10%): 4 - 6
  • Refractive index (25°C) : 1.430 - 1.440
  • Water Content (K. Fisher) : 22 - 28%
  • Pal VGVAPG content (HPLC) : 100 - 140 ppm
  • Bacteria : < 100 germs/g
  • Yeast and Molds : < 10 germs/g

Claim Substantiation

Sederma Yvelinescandex France

Clinical Study

A one month double-blind study was conducted on 10 female volunteers, aged 32 to 56. Twice daily applications of a light emulsion containing 4% BIOPEPTIDE EL against placebo. Elastic extensibility, tone, plasticity, skin fatigue and firmness parameters were measured using a fermometer.

In Vivo Tests

T: Skin tone
E: Elastic extensibility
FC: Cutaneous Fatigue (slackening)
P: Plasticity (flaccid skin)
F: Firmness (T/E ratio)
Increase in cutaneous firmness: +24.5%
  Variation Max Variations
Skin Tone +20%* +39%
Firmness +33%* +38 %
Slackening -17% * na
Flaccidity -19.6%* na

BIOPEPTIDE EL™, which contains a natural fragment of elastin characteristic of the repeated "spring structure”, has a restructuring and repairing effect on skin.

BIOPEPTIDE EL™ significantly improves firmness and tone of the skin.

Including Peptides and Actives is a great way to customize your own skin care line

We’ve all seen specialty serums, face and night creams with prices ranging anywhere from $70.00 to $100.00 or more for a 1/2 oz jar. What makes them so special? Great packaging and aggressive marketing work wonders, but the main thing that makes these products stand out from the rest is the use of Peptides and/or Actives. We at EBC are well aware that Peptides are among the most intriguing and sought-after skin care ingredients used in successful anti-ageing products today. Here we offer you BIOPEPTIDE EL™ a patented formulation (FR 2 668 365-FR 2 854 897-US 2004/0120918) from Sederma formulated in France.

But what are Peptides? What do Peptides do that other skin care ingredients don't do?

Peptides are short chains of Amino Acids, the basic building blocks of proteins and many other different types of organic molecules. Peptides are frequently created by the digestion of proteins in the body and many types of peptides are readily and rapidly absorbed by the bloodstream. For this reason, peptides are particularly effective as skin care ingredients.

Many peptides work as hormones, neurotransmitters and as natural pain relievers.

What do peptides do?

Different peptides have different effects. Peptides are a widely variable group of molecules, so speaking generally about the function of peptides is meaningless. Simply, there are four powerful peptides used in skin care products: acetyl hexapeptide-3, palmitoyl pentapeptide-3, palmitoyl oligopeptide and copper peptides. Here we will briefly discuss the function of Palmitoyl - Val - Gly - Val - Ala - Pro - Gly which is the peptide in BIOPEPTIDE EL™.

Palmitoyl Hexapeptide-12 (Palmitoyl-Valine-Glycine-Valine-Alanine-Proline-Glycine): This member of the peptides creates a response in the dermis of the skin that stimulates collagen and elastin fibroblasts, developing fibronectin (FN) and glycosaminoglycans (GAG). It is believed to work by reducing the production of interleukin-6 (IL-6) by the the key skin cells, keratinocytes and fibroblasts. IL-6 is a molecule that promotes inflammation, which, in turn, leads to faster degradation of the skin matrix and thus contributes to the development of wrinkles and loss of skin firmness and elasticity. By reducing the levels of IL-6 and possibly other inflammatory mediators, palmitoyl is thought to slow down the degradation of the skin matrix and may also stimulate its replenishment.

How do I use it?

As stated in the studies above add directly to your emulsions (lotions, creams, etc) at 45°C and into gels at room temperature. Use at a level of 2%-5%.

Looking for the ultimate combination of Biopeptides that will restructure the dermal matrix causing firming and anti-wrinkle action while increasing suppleness. A combination of both Biopeptide CL (collagen) and Biopeptide EL (elastin) will boost results considerably! Both are available here at Essentials By Catalina.
BIOPEPTIDE EL ™ is sold by weight in gel liquid form.

Additional Information

Unit Size 2 Fl. Oz. (Net Weight 2.5 Ounces)
Country of Origin France



The information in this publication is given in good faith by Sederma, Essentials By Catalina and/or Maki Creations, Inc. (the companies)by way of general guidance and for reference purposes only. The information should not be construed as granting a license to practice any methods or compositions of matter covered by patents. The companies assume no liability in relation to the information and gives no warranty regarding the suitability of the product and/or ingredients described for a particular use. The use made of the product and/or ingredients described by the recipient and any claims or representations made by the recipient in respect of such product and/or ingredients are the responsibility of the recipient. The recipient is solely responsible for ensuring that products marketed to consumers comply with all relevant laws and regulations. The companies are not responsible for product compatibility. We encourage everyone to beta test in controlled quantities prior to committing to larger quantities. It gives you a chance to test the product for product performance, compatibility and safety in regards to containers, applicators, closures and reactivity to other ingredients.

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